HomeScience and TechnologyHealthGirl Becomes Leukemia Free...

Girl Becomes Leukemia Free After Receiving World’s First Radical Cell-Engineered Therapy

A 13-year-old UK teenager has become ‘leukemia-free’ after she received the world’s first treatment of a new type of cell-engineering technology using ‘base-edited’ cells.

Alyssa, from Leicester, had undergone both chemotherapy and a bone marrow transplant in order to fight leukemia. Unfortunately, the treatments were unsuccessful and palliative care was the only option that was left for the girl.

But fate had something else in mind. Alyssa’s parents enrolled their daughter in a unique cell therapy. She was given an infusion of donated, healthy T-cells that were tweaked with the help of a technique known as base editing. Six months following the administration, Alyssa has remained in remission.

“We are in a strange cloud nine, to be honest. It’s amazing,” said her mother, Kiona, reported The Guardian.

“This is our most sophisticated cell engineering so far, and it paves the way for other new treatments and ultimately better futures for sick children,” immunologist Professor Waseem Qasim, one of the leaders of the project, said.

The results of the clinical trial will be presented at the American Society of Haematology meeting in New Orleans this weekend.

Alyssa was diagnosed with T-cell acute lymphoblastic leukemia (T-ALL) in 2021. It is a type of cancer that affects white blood cells called T-cells. These cells detect and destroy defective cells in the body.

She was given universal CAR (Chimeric Antigen Receptor) T-cells that had been pre-manufactured from a healthy volunteer donor in May this year

To counter the cancerous T-cells in Alyssa’s blood, the CAR T-cells were collected from a healthy donor and programmed to target other T-cells and kill them, including both normal and leukemia cells in the patient’s body. The T-cells were altered by base editing, which involves a single change in the multiple letters of DNA code. Changes were made in T-cells so that they do not kill each other in ‘friendly fire.’

“Once I do it, people will know what they need to do, one way or another, so doing this will help people – of course, I’m going to do it,” Alyssa said regarding the new therapy.

After infusion of base-edited T-cells, Alyssa underwent another bone-marrow transplant to replenish her depleted white blood cells reservoir.

“Hopefully this can prove the research works and they can offer it to more children – all of this needs to have been for something,” Alyssa’s mother commented.

The teenager was treated at Great Ormond Street Hospital for Children (GOSH) in London.

“This is an ‘off the shelf’ universal cell therapy and – if replicated – will mark a huge step forward in these types of treatments,” Dr. Louise Jones of the Medical Research Council, which funded the project, said.

Now, the team involved in the trial will recruit up to 10 patients with T-cell leukemia who, just like Alyssa, have tried all conventional treatment options for a clinical trial using the new cell therapy technique.

 

Most Popular

LEAVE A REPLY

Please enter your comment!
Please enter your name here

More from Author

Climate Change Fuels Rise In Antimicrobial Resistance: UN Report

Antimicrobial resistance is becoming prevalent due to climate change and other...

Mysterious Meningitis Kills At Least 35 In Mexico Amid Outbreak

Northern Mexico is still grappling with a mysterious meningitis outbreak after...

Vitamin D Effectively Prevents Type 2 Diabetes In 3 Clinical Trials

Pre-diabetic people could turn to vitamin D supplements for help in...

Read Now

Climate Change Fuels Rise In Antimicrobial Resistance: UN Report

Antimicrobial resistance is becoming prevalent due to climate change and other environmental factors, according to a report from the United Nations Environment Programme. The leading environmental authority in the United Nations system recently published a report entitled “Bracing for Superbugs: Strengthening environmental action in the One Health response to...

Rise In Maternal Mortality Prompts Proposal For Frequent Blood Pressure Monitoring During, After Pregnancy

Pregnant women in the U.S. are being obliged to have their blood pressure screened and monitored during and after their pregnancy in response to the rise in maternal mortality in the country. On Tuesday, the U.S. Preventive Services Task Force issued a draft recommendation proposing a mandatory screening...

Mysterious Meningitis Kills At Least 35 In Mexico Amid Outbreak

Northern Mexico is still grappling with a mysterious meningitis outbreak after state officials reported another fatality due to the condition on Monday, bringing the total number of deaths to 35. Specific details about the latest death amid the outbreak weren’t immediately available, but health authorities in Mexico’s rural...

Vitamin D Effectively Prevents Type 2 Diabetes In 3 Clinical Trials

Pre-diabetic people could turn to vitamin D supplements for help in preventing their condition from progressing to type 2 diabetes. This is what scientists discovered after conducting clinical trials with the supplements. Researchers found after three randomized clinical trials that vitamin D supplements are modestly effective in lowering the...

Interests of poor at centre of every budget presented by BJP Govt: Modi

STATE TIMES NEWS New Delhi: Prime Minister Narendra...

BJP wave sweeping across Meghalaya: Chugh

STATE TIMES NEWS MEGHALAYA: BJP National General Secretary...

JEE-Main result: 20 candidates score perfect 100, NTA score of 50 candidates withheld

STATE TIMES NEWS New Delhi: Twenty candidates have scored perfect 100 in engineering entrance exam JEE-Main’s January edition, the National Testing Agency (NTA) announced...

No. of medical colleges in India has gone up to 654 from 387 since 2014: Govt

NEW DELHI: There has been a 69-per cent increase in the number of medical colleges in the country, from 387 before 2014 to...

Doctors stage protest demanding postponement of NEET-PG exam

NEW DELHI: A group of doctors, including NEET-PG aspirants, held a protest at the Jantar Mantar Road here on Tuesday, demanding the postponement...

AgustaWestland chopper scam: SC denies bail to alleged middleman Christian Michel James

NEW DELHI: The Supreme Court on Tuesday denied bail to Christian Michel James, an alleged middlemen in AgustaWestland chopper scam cases, who is...

India can be superpower in defence manufacturing: General Chauhan

PUNE: Lauding the private sector contribution in defence manufacturing, Chief of Defence Staff (CDS) General Anil Chauhan on Tuesday said India has the...

India hits out at Pakistan for raking up Kashmir issue at UN

UNITED NATIONS: India has slammed Pakistan for raking up the Kashmir issue in the United Nations, saying Islamabad harbours a deep sense of...