HomeScience and TechnologyHealthCommon Acne Treatment In...

Common Acne Treatment In Adolescents Can Have Long-Term Effects On Skeletal System: Study

Teenagers with acne may need to think twice before starting a common antibiotic treatment meant to resolve skin issues. A new study has found that antibiotic treatment may alter the skeletal system with long-lasting effects.

The study, published in the Journal of Clinical Investigation (JCI) Insight, showed that long-term topical use of a systemic antibiotic, minocycline, may have unintended effects during adolescent bone development.

Minocycline treatment can last for up to two years. This antibiotic alters the gut microbiome—the population of microorganisms that live in the gut.

Researchers from the Medical University of South Carolina (MUSC) found a strong correlation between the composition of the gut microbiome and healthy skeletal maturation.

For the study, the research team gave an appropriate dose of minocycline to mice during the pubertal/postpubertal growth stage, which is the equivalent age of adolescence in humans.

It was found in the study that though minocycline therapy did not cause any cytotoxic effects or induce a pro-inflammatory response, it did change the composition of the gut microbiome which led to decreased bone mass accrual and inefficient skeletal maturation.

“There are sustained changes to the gut microbiome following long-term systemic minocycline therapy that leads to reduced bone maturation,” first author, Matthew Carson, Novince lab, said, reported SciTechDaily.

“From a clinical perspective, not only is minocycline treatment causing changes to the maturing skeleton, the microbiome and the skeleton aren’t able to recover fully after antibiotic therapy,” Chad Novince, principal investigator and associate professor in the Department of Oral Health Sciences in the College of Dental Medicine added.

Minocycline belongs to the tetracycline class of antibiotics. This group also includes antibiotics such as tetracycline, doxycycline, and sarecycline. These antibiotics work by obstructing the growth and spread of bacteria. In the case of acne, they kill the bacteria that infect pores and reduce certain acne-causing natural oily substances.

“What’s really interesting is if you cause changes to the microbiome during this adolescent phase when your microbiota is still progressing toward a stable adult state, you’re going to have profound effects on the maturing skeleton,” Carson said, as per the outlet.

Interestingly, the team found that the changes in the gut microbiome due to minocycline also affected the communication between the liver and the small intestine, which takes place through molecules called bile acids.

“Bile acids had not previously been considered as important communication molecules between the gut and the skeleton,” Novince said, according to the outlet. “By changing the gut microbiome, the makeup of the bile acids is altered, which influences host physiology, including skeletal maturation.”

The altered gut microbiome created a different pool of bile acids. These different types of bile acids could not activate bone-forming cells called osteoblasts, which, in turn, decreased bone formation and mineralization by more than 30%.

“This was truly collaborative science, which is where I think we’re at today,” Novince said. “To drive high-impact science, you need to bring in experts from different professions and disciplines. We were fortunate to have a really strong team. It was fun – the whole thing was exciting!”

Most Popular

LEAVE A REPLY

Please enter your comment!
Please enter your name here

More from Author

Study Narrows Down Long COVID Symptoms To Just 7

Long COVID, the medical mystery that continues to boggle the minds...

Depressed Young Adults Likely To Develop Heart Disease And Vice-Versa

Young adults or people in the 18-25 age group are at...

More Women Are Dying From ‘Preventable’ Cervical Cancer: Study

More older women have succumbed to cervical cancer in recent years,...

Read Now

Study Narrows Down Long COVID Symptoms To Just 7

Long COVID, the medical mystery that continues to boggle the minds of scientists and medical researchers, comes with an extensive list of symptoms. But a new study narrowed down the 47 reported symptoms to just seven. Published in the journal Open Forum Infectious Disease, the study by the...

Depressed Young Adults Likely To Develop Heart Disease And Vice-Versa

Young adults or people in the 18-25 age group are at risk of suffering two serious health issues: depression and heart disease. A new study found a “two-way street” relationship between depression and an increased risk of cardiovascular disease (CVD) in younger adults. According to the Johns Hopkins Medicine...

Obesity Found To Cause Alzheimer’s-Like Condition; Weight Loss Reduces Risk

Obese people are at risk of suffering a condition similar to Alzheimer’s disease. But this can be countered by healthy weight loss. A McGill University study published Tuesday in the Journal of Alzheimer’s Disease presented a correlation between obesity-associated neurodegeneration and Alzheimer’s. Using data from the Alzheimer’s Disease Neuroimaging...

More Women Are Dying From ‘Preventable’ Cervical Cancer: Study

More older women have succumbed to cervical cancer in recent years, even though the condition is  preventable. A new study from the University of California, Davis found a spike in older women suffering from late-stage cancer. And since they develop the disease at an older age, their chances...

Befitting response given to every ‘misadventure’ from LoC to LAC: President Murmu

NEW DELHI: President Droupadi Murmu on Tuesday said the government has been laying constant emphasis on modernising the military as it firmly believes...

NIA files chargesheet against IS operative for conspiring to recruit youth for terror activities in India

NEW DELHI: The National Investigation Agency (NIA) on Tuesday filed a chargesheet against an accused in a case related to a conspiracy hatched...

First-Of-Its-Kind $1 Glove Can Detect Fetal Positions To Aid Precarious Births

An ingenious innovation of a smart glove that costs less than $1 has been created with the aim to aid clinicians during birth. The study, published in the open-access journal Frontiers in Global Women’s Health, engineered the device to help healthcare staff in finding the fetal position and the...

Study Finds Threatened Sharks Being Served In Fish Fillets

The ultimate British dish--fish and chips--have takers all over the world. However, the fish served in the dish might actually be an endangered shark species.A recent study, published in the journal Food Control, found shocking samples of endangered shark species in several fish filets served at more...

Coffee With Milk Has Strong Anti-Inflammatory Effect: Study

An ardent proponent of the benefits of black coffee? You might have to change allegiance, as a new study has found coffee with milk has synergistic properties that increase its anti-inflammatory effect.The study, published in the Journal of Agricultural and Food Chemistry, found that the antioxidants from coffee combined...

All-Party Meet ahead of Budget Session held

STATE TIMES NEWS New Delhi: The government on...

This Is How Many Adult Americans Are Addicted To Junk Food

More older adults in the United States have become addicted to processed food, according to a recent University of Michigan poll. The school’s National Poll on Health Aging presented alarming findings in its January-February 2023 issue, saying that based on the latest data, 1 in 8 adults over...

Bengaluru colleges ban use of ChatGPT, the AI agent that writes assignments

At a time when the use of AI tools has grown exponentially, plagiarism is becoming an increasingly pressing issue for universities. RV University in Bengaluru has recently taken steps to curb the use of such tools, particularly ChatGPT, by banning it altogether. The move is supported by...